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Miss Asma Khalil
24
Apr

New Article – Twin growth charts for stillbirth: a validation study

The validation study for customised twin growth charts has bee published here.  It is hoped that these charts will improve care in twin pregnancies and reduced the rate of stillbirths.

Predictive accuracy of the Southwest Thames Obstetric Research Collaborative (STORK) chorionicity-specific twin growth charts for stillbirth: a validation study.

Kalafat E1,2,3, Sebghati M1, Thilaganathan B1, Khalil A1; Southwest Thames Obstetric Research Collaborative (STORK).

Ultrasound Obstet Gynecol. 2018 Apr 16. doi: 10.1002/uog.19069. [Epub ahead of print]

Abstract
OBJECTIVE:
Twin pregnancy is associated with 2-3 fold increased risk of stillbirth compared to singletons. Despite the fact that the growth pattern has been shown to differ in twins compared to singletons, it is controversial whether twin-specific growth charts should be routinely used. A major goal of prenatal ultrasound is to identify fetuses suffering fromgrowth restriction at risk of stillbirth. The main aim of this study was to compare the performance of chorionicity-specifictwin charts with singleton charts, both customized and non-customized, in the antenatal prediction of small-for-gestational age (SGA) stillborn and liveborn fetuses.
METHODS:
This was a multicenter cohort study analyzing data from the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort (2000-2009) and a second cohort of twin pregnancies at St. George’s University Hospital (SGH) (2011-2016). The former cohort was used to compare the performance of the twin and non-customized (Poon) singleton charts. The latter cohort was used to compare the performance of the twin, customized (Gestation Related Optimal Weight [GROW]) and non-customized (Poon) singleton charts. The primary outcome was the prediction of SGA cases that were stillborn and liveborn in twin pregnancies. The estimated fetal weight (EFW) available from the last scan (24 weeks’ gestation and onwards) before delivery or demise was used to classify the fetuses as SGA (<10th centile, <3rd centile) or appropriate for gestational age. The proportions of SGA stillbirths and SGA livebirths predicted were calculated using the three different charts.
RESULTS:
The STORK cohort consisted of 1850 dichorionic (DC) and 300 monochorionic (MC) twin pregnancies. The SGH cohort consisted of 579 DC and 180 MC twin pregnancies. The stillbirth rate in the STORK and SGH cohorts were 1.1% and 1.3%, respectively. In those liveborn in the STORK cohort, using a 10th centile cut-off to define SGA, the non-customized singleton chart identified a significantly greater proportion as SGA compared to the twin chart, regardless of chorionicity (p<0.001). However, there was no significant difference between the twin and the non-customized singletoncharts in regards to in the proportion of stillbirth cases that were SGA (p=0.479). In the SGH cohort, the non-customized singleton chart identified 8.5% of all liveborn fetuses as SGA (<10th centile) compared to 12.8% using the customized singleton chart and 7.1% using the twin chart (p=0.005 and p<0.001, respectively). However, there was no significant difference among the three charts in the proportion of stillbirths identified as SGA, regardless of chorionicity (p=0.999). Similar results were obtained when the third centile cut-off was used to define SGA.
CONCLUSIONS:
Compared to the STORK chorionicity-specific twin charts, the customized or non-customized singleton charts identified more liveborn fetuses as SGA. However, the three charts identified a similar proportion of stillbirth SGA cases. Our preliminary results suggest that these twin charts could safely reduce unnecessary medical intervention in twin pregnancies. Further research on the topic is needed before clinical recommendations can be made.

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